p450 uchc.edu

John B. Schenkman Lab - P450 - UConn Health Center

Our research revolves around the hemoprotein enzymes cytochrome P450, an enzyme superfamily that we have studied for more than three decades.
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Department of Cell Biology - UConn Health

Research in the Department of Cell Biology is concerned with cells as well as how cells function in the context of the various tissues of the body. Our goal is to discover molecular and physiological mechanisms that underlie the treatment and prevention of human disease. In the July 18, 2013 issue of Cell.

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John B. Schenkman Lab - P450 - UConn Health Center

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Our research revolves around the hemoprotein enzymes cytochrome P450, an enzyme superfamily that we have studied for more than three decades.

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The domain p450.uchc.edu states the following, "The figure shows the crystal structure of a cytochrome P450 CYP, CYP1A2, which is related to CYP1B1, an un-crystallized form in which mutations are linked to primary congenital glaucoma, with which it has been aligned." We observed that the webpage also said " Choudhary D, Jansson I, Sarfarazi M, Schenkman JB Characterization of the biochemical and structural phenotypes of four CYP1B1 mutations observed in individuals with primary congenital glaucoma."

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